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The duloxetine treatment recommendation for CIPN is based on the results from a randomized controlled trial in 231 patients taking oxaliplatin or taxanes, which found that those receiving duloxetine (30 mg/day for one week followed by 60 mg/day for an additional four weeks) reported greater reduction in pain than those in the placebo group (Smith 2013)

Hepatotoxicity associated with antiepileptic drugs

Xplosiv makes no fat-loss, weight-management, energy or cognitive claims for it